A Simple Elegant Solution to Address DANE

AMDS Hybrid Prosthesis

PTFE felt graft component made of a PTFE felt tube is used to buttress and strengthen the aortic tissue in preparation to perform the conventional polyester graft to aorta anastomosis.15

Uncovered nitinol wire braided stent enables the stabilization of the dissection flap within the aortic arch and descending aorta thereby stabilizing the structure of the aortic wall and promoting healing of the wall.15,16

The AMDS device comes pre-mounted on a delivery system. There is no need for X-Ray, fluoroscopy or hybrid room to use the AMDS system.15

The AMDS Hybrid Prosthesis Simply Elevates the Standard of Care for Acute TAAD

Hemiarch Repair

Aortic Hemiarch Repair

1. Replace the ascending aorta

2. Seal the distal anastomotic entry tear (DANE)16

3. Stabilize the true lumen16


Induce Remodeling6,9,12

Surgical Repair + AMDS

Distal Anastomotic New Entry and Plus Hemiarch Repair

Comparison of Standard Surgical Repair vs. Surgical Repair with AMDS

Comparison of Standard Surgical Repair vs. Surgical Repair with AMDS

Case Example

Pre-operative images of dissection and malperfusion of left common carotid and common femoral arteries

CT-Scan-1
CT-Scan-2
CT-Scan-3
CT-Scan-4

Remodeling and complete resolution of malperfusion post AMDS implantation

CT-Scan-5
CT-Scan-6
CT-Scan-7

References:
1. Bonser et al. J Am Coll Cardiol 2011;58:2455–74.  2. Pepper J et al. Ann Cardiothorac Surg 2016;5(4):360-367. 3. Chin et al. J Am Coll Cardiol. 2018 June 19; 71(24): 2773–2785. 4. Nardi et al. Vessel Plus 2017;1:77-83.5. Merkle et al. Ther Adv Cardiovasc Dis 2018, Vol. 12(12) 327–340. 6. Rylski et al. Eur J Cardiothorac Surg 2017;51:1127–34. 7. Czerny et al. J Vis Surg 2018;4:14. 8. Shrestha  et al.. Eur J Cardiothorac Surg 2017;51:i34–i39. 9. Tamura et al Eur J Cardiothorac Surg 2017;52:867–73. 10. Bing et al Vascular and Endovascular Surgery 2014, Vol. 48(3) 239-245. 11. Fattouch et al Ann Thorac Surg 2009;88:1244–50. 12. Evangelista et al. Circulation. 2012;125:3133-3141. 13. Geirsson A, et al. Eur J Cardio-Thorac Surg, 2007;32(2):255-262.  14. Czerny M, et al. JACC 2015;65(24):2628-2635. 15. Instructions for Use (IFU), Ascyrus Medical Dissection Stent. 16. Journal Pre-proof of Bozso SJ et al. “Midterm Outcomes of the Dissected Aorta Repair Through Stent Implantation Trial”, The Annals of Thoracic Surgery (2020), doi: https://doi.org/10.1016/ j.athoracsur.2020.05.090. 17. Lee TC et al. J Card Surg. 2018;33:7–18. 18. Easo J et al. J Thorac Cardiovasc Surg 2012;144:617-23. 19. Grimm JC et al. Ann Cardiothorac Surg 2016;5(3):202-208.  20. Dumfarth J et al. Eur J Cardiothorac Surg 2018;53:1013–2.